ADMET-AI

ADMET: The evaluation of pharmacokinetics and toxicity is crucial for the design of new therapeutic candidates. In silico virtual screens and generative AI output a vast number of molecules that must be filtered to a tractable number for synthesis and experimental validation. An effective primary filter is to evaluate candidate compounds based on their Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties.

ADMET-AI: ADMET-AI is a simple, fast, and accurate web interface for predicting the ADMET properties of molecules using machine learning models.

Models: ADMET-AI predicts ADMET properties using a graph neural network architecture called Chemprop-RDKit (see the Chemprop package for details). ADMET-AI's Chemprop-RDKit models were trained on 41 ADMET datasets from the Therapeutics Data Commons (TDC). ADMET-AI’s Chemprop-RDKit models have the highest average rank on the TDC ADMET Benchmark Group leaderboard. ADMET-AI is also currently the fastest web-based ADMET predictor.

References: The ADMET-AI code can be found at github.com/swansonk14/admet_ai, and ADMET-AI is described in detail in this paper: ADMET-AI: A machine learning ADMET platform for evaluation of large-scale chemical libraries. Please cite us if ADMET-AI is useful in your work.


Input

Molecules: ADMET-AI can make predictions for up to 1,000 molecules at a time by (1) providing SMILES (one per line) in the text box, (2) uploading a CSV file with SMILES, or (3) drawing a molecule using the interactive tool and then converting it to a SMILES.

DrugBank Reference: To provide relevant context, ADMET predictions on input molecules are compared to predictions on 2,579 approved drugs from the DrugBank. This reference set can be filtered to a specific category of drugs for a more relevant comparison by selecting an Anatomical Therapeutic Chemical (ATC) code.

Predict: After selecting input molecules and a DrugBank reference set, click the “Predict” button to make ADMET predictions.

Output

Summary Plot: The summary plot shows the distribution of ADMET predictions for all input molecules compared to the DrugBank reference set. The x- and y-axes can be changed to show any two ADMET properties.

Radial Plot: For each input molecule, a radial plot is shown summarizing five key ADMET properties in terms of their DrugBank percentile:

  1. Blood-Brain Barrier Safe: The probability that the molecule does not cross the blood-brain barrier (i.e., 1 - Blood-Brain Barrier Penetration percentile).
  2. hERG Safe: The probability that the molecule does not block the human ether-a-go-go (hERG) channel (i.e., 1 - hERG Blocking percentile).
  3. Bioavailable: The probability that the molecule is orally bioavailable (i.e., Oral Bioavailability percentile).
  4. Soluble: The aqueous solubility of the molecule (i.e., Aqueous Solubility percentile).
  5. Non-Toxic: The probability that the molecule is not toxic across all toxicity properties (i.e., 1 - maximum Toxicity percentile).

ADMET Predictions: Clicking on each displayed molecule will show the molecule’s ADMET predictions in tabular form. For each molecule, ADMET-AI computes 8 physicochemical properties using RDKit and predicts 41 ADMET properties using its Chemprop-RDKit graph neural networks. For regression properties, the property is directly predicted with the units shown. For classification properties, the predicted value is the probability that the molecule has the property (e.g., probability of blood-brain barrier penetration). Additionally, the percentile of the molecule’s property compared to the DrugBank reference is shown.

Download Predictions: Predictions for the first 25 molecules are shown on the website. Predictions for all input molecules can be downloaded as a CSV file by clicking the “Download Results” button.

Notes

Storing Molecules: ADMET-AI does not store any molecules uploaded to the website. All molecules are deleted after predictions are made.


ADMET-AI can be run locally as a command line tool for large-scale batch prediction or as a Python module for use within other Python-based drug discovery tools. Please see github.com/swansonk14/admet_ai for more details.

Predict

Input up to 1,000 molecules to make ADMET predictions.

SMILES (one per line)
CSV file containing SMILES in the provided column
SMILES column:
Draw a molecule

DrugBank Reference

Create a DrugBank reference set to provide context for ADMET predictions.

Choose an Anatomical Therapeutic Chemical (ATC) code to select a subset of DrugBank approved drugs or choose "all" for all approved drugs.

Selected ATC code "all" includes 2,579 molecules.

  • all 2-amino-1-phenylethanol derivatives 3-oxoandrosten (4) derivatives ace inhibitors and calcium channel blockers ace inhibitors and diuretics ace inhibitors, combinations ace inhibitors, other combinations ace inhibitors, plain acetic acid derivatives and related substances acid preparations acidifiers acth actinomycines adamantane derivatives adrenergic and dopaminergic agents adrenergics for systemic use adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics adrenergics, inhalants agents acting on the renin-angiotensin system agents against amoebiasis and other protozoal diseases agents against leishmaniasis and trypanosomiasis agents for dermatitis, excluding corticosteroids agents for treatment of hemorrhoids and anal fissures for topical use aldehydes and derivatives aldosterone antagonists aldosterone antagonists and other potassium-sparing agents alimentary tract and metabolism alkyl sulfonates alkylating agents all other therapeutic products alpha and beta blocking agents alpha and beta blocking agents and other diuretics alpha and beta blocking agents and thiazides alpha glucosidase inhibitors alpha- and beta-adrenoreceptor agonists alpha-adrenoreceptor antagonists alpha-adrenoreceptor antagonists and diuretics aluminium compounds amides amino acids amino acids and derivatives aminoalkyl ethers aminoglycoside antibacterials aminoquinolines aminosalicylic acid and derivatives aminosalicylic acid and similar agents amphenicols anabolic agents for systemic use anabolic steroids analgesics analgesics and anesthetics anaplastic lymphoma kinase (alk) inhibitors androgens androgens and estrogens androgens and female sex hormones in combination androgens and female sex hormones in combination with other drugs androstan derivatives anesthetics anesthetics for topical use anesthetics, general anesthetics, local angiotensin ii receptor blockers (arbs) and calcium channel blockers angiotensin ii receptor blockers (arbs) and diuretics angiotensin ii receptor blockers (arbs), combinations angiotensin ii receptor blockers (arbs), other combinations angiotensin ii receptor blockers (arbs), plain anilides antacids antacids with antiflatulents anterior pituitary lobe hormones and analogues anthelmintics anthracyclines and related substances anti-acne preparations anti-acne preparations for systemic use anti-acne preparations for topical use anti-androgens anti-dementia drugs anti-estrogens anti-gonadotropin-releasing hormones anti-parathyroid agents anti-parkinson drugs antiadrenal preparations antiadrenergic agents, centrally acting antiadrenergic agents, ganglion-blocking antiadrenergic agents, peripherally acting antiallergic agents, excl. corticosteroids antiandrogens antiandrogens and estrogens antiandrogens, plain antianemic preparations antiarrhythmics, class i and iii antiarrhythmics, class ia antiarrhythmics, class ib antiarrhythmics, class ic antiarrhythmics, class iii antibacterials for systemic use antibiotics antibiotics and chemotherapeutics for dermatological use antibiotics for topical use anticestodals anticholinergic agents anticholinergics anticholinesterases anticorticosteroids antidepressants antidepressants in combination with psycholeptics antidiarrheals, intestinal antiinflammatory/antiinfective agents antidotes antiemetics and antinauseants antiepileptics antifibrinolytics antifungals for dermatological use antifungals for systemic use antifungals for topical use antiglaucoma preparations and miotics antigonadotropins and similar agents antigout preparations antihemorrhagics antihidrotics antihistamines for systemic use antihistamines for topical use antihypertensives antihypertensives and diuretics in combination antihypertensives for pulmonary arterial hypertension antiinfectives antiinfectives and antiseptics for local oral treatment antiinfectives and antiseptics, excl. combinations with corticosteroids antiinfectives for systemic use antiinfectives for treatment of acne antiinflammatory agents antiinflammatory agents and antiinfectives in combination antiinflammatory agents, non-steroids antiinflammatory agents, non-steroids and antiinfectives in combination antiinflammatory and antirheumatic products antiinflammatory and antirheumatic products, non-steroids antiinflammatory preparations, non-steroids for topical use antiinflammatory products for vaginal administration antiinflammatory/antirheumatic agents in combination antiinflammatory/antirheumatic agents in combination with corticosteroids antimalarials antimetabolites antimigraine preparations antimony compounds antimycobacterials antimycotics for systemic use antinematodal agents antineoplastic agents antineoplastic and immunomodulating agents antineovascularisation agents antiobesity preparations, excl. diet products antiparasitic products, insecticides and repellents antipropulsives antiprotozoals antipruritics, incl. antihistamines, anesthetics, etc. antipsoriatics antipsoriatics for systemic use antipsoriatics for topical use antipsychotics antiseptics antiseptics and disinfectants antispasmodics in combination with analgesics antispasmodics in combination with psycholeptics antithrombotic agents antithyroid preparations antitrematodals antivaricose therapy antivertigo preparations antivirals antivirals for systemic use antivirals for treatment of hcv infections antivirals for treatment of hiv infections, combinations antracen derivatives anxiolytics aromatase inhibitors arsenic compounds artemisinin and derivatives, combinations artemisinin and derivatives, plain arteriolar smooth muscle, agents acting on aryloxyacetic acid derivatives ascorbic acid (vitamin c), combinations ascorbic acid (vitamin c), incl. combinations ascorbic acid (vitamin c), plain avermectines azaspirodecanedione derivatives b-raf serine-threonine kinase (braf) inhibitors barbiturates and derivatives barbiturates, combinations barbiturates, plain barium sulfate containing x-ray contrast media bcr-abl tyrosine kinase inhibitors belladonna alkaloids, semisynthetic, quaternary ammonium compounds belladonna alkaloids, tertiary amines belladonna and derivatives in combination with analgesics belladonna and derivatives in combination with psycholeptics belladonna and derivatives, plain benzamides benzimidazole derivatives benzodiazepine derivatives benzodiazepine related drugs benzomorphan derivatives benzothiazepine derivatives beta blocking agents beta blocking agents and calcium channel blockers beta blocking agents and other diuretics beta blocking agents and thiazides beta blocking agents, non-selective beta blocking agents, non-selective, and other diuretics beta blocking agents, non-selective, and thiazides beta blocking agents, non-selective, thiazides and other diuretics beta blocking agents, other combinations beta blocking agents, selective beta blocking agents, selective, and other diuretics beta blocking agents, selective, and thiazides beta blocking agents, selective, thiazides and other diuretics beta blocking agents, thiazides and other diuretics beta-lactam antibacterials, penicillins beta-lactamase inhibitors beta-lactamase resistant penicillins beta-lactamase sensitive penicillins biguanides biguanides and amidines bile acids and derivatives bile and liver therapy bile therapy bioflavonoids bisphosphonates bisphosphonates, combinations blood and blood forming organs blood glucose lowering drugs, excl. insulins blood substitutes and perfusion solutions bruton's tyrosine kinase (btk) inhibitors butylpyrazolidines butyrophenone derivatives calcineurin inhibitors calcitonin gene-related peptide (cgrp) antagonists calcium calcium channel blockers calcium channel blockers and diuretics calcium compounds calcium homeostasis capillary stabilizing agents capsaicin and similar agents carbamates carbamic acid esters carbamide products carbapenems carbohydrates carbonic anhydrase inhibitors carboxamide derivatives cardiac glycosides cardiac stimulants excl. cardiac glycosides cardiac therapy cardiovascular system caries prophylactic agents central nervous system centrally acting antiobesity products centrally acting sympathomimetics charcoal preparations chemotherapeutics for topical use chlorine containing products choline derivatives choline esters cicatrizants colouring agents combinations and complexes of aluminium, calcium and magnesium compounds combinations for eradication of helicobacter pylori combinations of antibacterials combinations of antineoplastic agents combinations of drugs for treatment of tuberculosis combinations of oral blood glucose lowering drugs combinations of penicillins, incl. beta-lactamase inhibitors combinations of sulfonamides and trimethoprim, incl. derivatives combinations of various lipid modifying agents contact laxatives contraceptives for topical use contrast media corticosteroids corticosteroids acting locally corticosteroids and antiinfectives in combination corticosteroids and mydriatics in combination corticosteroids for local oral treatment corticosteroids for systemic use corticosteroids for systemic use, combinations corticosteroids for systemic use, plain corticosteroids, combinations for treatment of acne corticosteroids, combinations with antibiotics corticosteroids, combinations with antiseptics corticosteroids, dermatological preparations corticosteroids, moderately potent (group ii) corticosteroids, moderately potent, combinations with antibiotics corticosteroids, moderately potent, combinations with antiseptics corticosteroids, moderately potent, other combinations corticosteroids, other combinations corticosteroids, plain corticosteroids, potent (group iii) corticosteroids, potent, combinations with antibiotics corticosteroids, potent, combinations with antiseptics corticosteroids, potent, other combinations corticosteroids, very potent (group iv) corticosteroids, very potent, combinations with antibiotics corticosteroids, weak (group i) corticosteroids, weak, combinations with antibiotics corticosteroids, weak, combinations with antiseptics corticosteroids, weak, other combinations corticosteroids/antiinfectives/mydriatics in combination cough and cold preparations cough suppressants, excl. combinations with expectorants coxibs curare alkaloids cyclic amines cyclin-dependent kinase (cdk) inhibitors cytotoxic antibiotics and related substances dantrolene and derivatives decongestants and antiallergics decongestants and other nasal preparations for topical use dermatologicals detoxifying agents for antineoplastic treatment diagnostic agents diagnostic radiopharmaceuticals diaminopyrimidines diazepines, oxazepines, thiazepines and oxepines dichloroacetamide derivatives digestives, incl. enzymes digitalis glycosides dihydropyridine derivatives dipeptidyl peptidase 4 (dpp-4) inhibitors diphenylbutylpiperidine derivatives diphenylmethane derivatives diphenylpropylamine derivatives direct acting antivirals direct factor xa inhibitors direct thrombin inhibitors diuretics diuretics and potassium-sparing agents in combination dopa and dopa derivatives dopamine agonists dopaminergic agents drugs affecting bone structure and mineralization drugs for acid related disorders drugs for constipation drugs for functional gastrointestinal disorders drugs for obstructive airway diseases drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) drugs for treatment of bone diseases drugs for treatment of hypercalcemia drugs for treatment of hyperkalemia and hyperphosphatemia drugs for treatment of hypoglycemia drugs for treatment of lepra drugs for treatment of tuberculosis drugs for urinary frequency and incontinence drugs used in addictive disorders drugs used in alcohol dependence drugs used in benign prostatic hypertrophy drugs used in diabetes drugs used in erectile dysfunction drugs used in hereditary angioedema drugs used in nicotine dependence drugs used in opioid dependence ectoparasiticides, incl. scabicides ectoparasiticides, incl. scabicides, insecticides and repellents electrolyte solutions emergency contraceptives emollients and protectives endocrine therapy enemas epidermal growth factor receptor (egfr) tyrosine kinase inhibitors ergot alkaloids ergot alkaloids and oxytocin incl. analogues, in combination esters of aminobenzoic acid esters of benzoic acid estren derivatives estrogens estrogens, combinations with other drugs ethers chemically close to antihistamines ethers of tropine or tropine derivatives ethers, chemically close to antihistamines ethylene imines expectorants expectorants, excl. combinations with cough suppressants fatty acid derivatives fenamates fibrates fibroblast growth factor receptor (fgfr) tyrosine kinase inhibitors first-generation cephalosporins fluoride fluoroquinolones folic acid analogues folic acid and derivatives fourth-generation cephalosporins general nutrients genito urinary system and sex hormones glucagon-like peptide-1 (glp-1) analogues glucocorticoids glycopeptide antibacterials gold preparations gonadotropin releasing hormone analogues gonadotropin-releasing hormones gonadotropins and other ovulation stimulants guanidine derivatives guanidine derivatives and diuretics gynecological antiinfectives and antiseptics h2-receptor antagonists halogenated hydrocarbons hedgehog pathway inhibitors heparins or heparinoids for topical use hepatic and reticulo endothelial system high-ceiling diuretics high-ceiling diuretics and potassium-sparing agents histone deacetylase (hdac) inhibitors hmg coa reductase inhibitors hormonal contraceptives for systemic use hormone antagonists and related agents hormones and related agents human epidermal growth factor receptor 2 (her2) tyrosine kinase inhibitors hydantoin derivatives hydrazides hydrazinophthalazine derivatives hydrazinophthalazine derivatives and diuretics hydroxyquinoline derivatives hypnotics and sedatives hypnotics and sedatives in combination, excl. barbiturates hypothalamic hormones i.v. solution additives i.v. solutions imidazole and triazole derivatives imidazole derivatives imidazoline derivatives imidazoline receptor agonists imidazoline receptor agonists in combination with diuretics imidazothiazole derivatives immunostimulants immunosuppressants indium (111in) compounds indole derivatives insecticides and repellents integrase inhibitors intermediate-acting sulfonamides intestinal adsorbents intestinal antiinfectives intestinal antiinflammatory agents intravaginal contraceptives iodine (123i) compounds iodine (131i) compounds iodine products iron bivalent, oral preparations iron chelating agents iron in combination with folic acid iron in other combinations iron preparations iron trivalent, oral preparations irrigating solutions janus-associated kinase (jak) inhibitors leukotriene receptor antagonists lincosamides lipid modifying agents lipid modifying agents in combination with other drugs lipid modifying agents, combinations lipid modifying agents, plain liver therapy liver therapy, lipotropics local anesthetics local hemostatics long-acting sulfonamides low-ceiling diuretics and potassium-sparing agents low-ceiling diuretics, excl. thiazides low-ceiling diuretics, thiazides lung surfactants macrolides macrolides, lincosamides and streptogramins magnesium magnesium compounds magnetic resonance imaging contrast media mammalian target of rapamycin (mtor) kinase inhibitors mao inhibitors mao inhibitors and diuretics medical gases medicated dressings medicated dressings with antiinfectives medicated shampoos melatonin receptor agonists mercurial products methanolquinolines methyldopa methylhydrazines mineral supplements mineralocorticoids mitogen-activated protein kinase (mek) inhibitors monoamine oxidase a inhibitors monoamine oxidase b inhibitors monoamine oxidase inhibitors, non-selective monobactams morphinan derivatives mucolytics multivitamins with minerals multivitamins, combinations muscle relaxants muscle relaxants, centrally acting agents muscle relaxants, directly acting agents muscle relaxants, peripherally acting agents musculo-skeletal system mydriatics and cycloplegics nasal decongestants for systemic use nasal preparations natural and semisynthetic estrogens, plain natural opium alkaloids nerve depressants nervous system neuraminidase inhibitors nicotinic acid and derivatives nitroferricyanide derivatives nitrofuran derivatives nitrogen mustard analogues nitroimidazole derivatives nitrosoureas non-nucleoside reverse transcriptase inhibitors non-selective beta-adrenoreceptor agonists non-selective calcium channel blockers non-selective monoamine reuptake inhibitors non-watersoluble x-ray contrast media nucleoside and nucleotide reverse transcriptase inhibitors nucleosides and nucleotides excl. reverse transcriptase inhibitors ocular vascular disorder agents ophthalmological and otological preparations ophthalmologicals opioid anesthetics opioids opioids in combination with antispasmodics opioids in combination with non-opioid analgesics opium alkaloids and derivatives organic acids organic nitrates oripavine derivatives osmotically acting laxatives other agents acting on the renin-angiotensin system other agents against amoebiasis and other protozoal diseases other agents against leishmaniasis and trypanosomiasis other agents for local oral treatment other agents for treatment of hemorrhoids and anal fissures for topical use other alimentary tract and metabolism products other alkylating agents other aminoglycosides other analgesics and antipyretics other anti-acne preparations for topical use other anti-dementia drugs other anti-parathyroid agents other antiallergics other antianemic preparations other antiarrhythmics, class i and iii other antibacterials other antibiotics for topical use other antidepressants other antiemetics other antiepileptics other antifungals for topical use other antiglaucoma preparations other antihistamines for systemic use other antihypertensives other antihypertensives and diuretics other antiinfectives other antiinfectives and antiseptics other antiinflammatory and antirheumatic agents, non-steroids other antimalarials other antimigraine preparations other antimycotics for systemic use other antinematodals other antineoplastic agents other antiobesity drugs other antiparkinson drugs other antipruritics other antipsoriatics for topical use other antipsychotics other antiseptics and disinfectants other antithrombotic agents other antitrematodal agents other antivirals other beta-lactam antibacterials other blood glucose lowering drugs, excl. insulins other capillary stabilizing agents other cardiac preparations other cardiac stimulants other cardiovascular system diagnostic radiopharmaceuticals other central nervous system diagnostic radiopharmaceuticals other centrally acting agents other cephalosporins and penems other chemotherapeutics other cicatrizants other cough suppressants other cytotoxic antibiotics other dermatological preparations other dermatologicals other diagnostic agents other diagnostic radiopharmaceuticals for tumour detection other diuretics other dopaminergic agents other drugs affecting bone structure and mineralization other drugs for bile therapy other drugs for constipation other drugs for disorders of the musculo-skeletal system other drugs for functional gastrointestinal disorders other drugs for obstructive airway diseases, inhalants other drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) other drugs for treatment of tuberculosis other ectoparasiticides, incl. scabicides other estrogens other general anesthetics other gynecologicals other hematological agents other hormone antagonists and related agents other hypnotics and sedatives other i.v. solution additives other immunostimulants other immunosuppressants other insecticides and repellents other intestinal adsorbents other intestinal antiinfectives other irrigating solutions other lipid modifying agents other local anesthetics other mineral supplements other nasal preparations other nervous system drugs other non-selective calcium channel blockers other nutrients other ophthalmologicals other opioids other otologicals other parasympathomimetics other peripheral vasodilators other plain vitamin preparations other plant alkaloids and natural products other potassium-sparing agents other protein kinase inhibitors other psychostimulants and nootropics other quaternary ammonium compounds other quinolones other renal system diagnostic radiopharmaceuticals other respiratory system diagnostic radiopharmaceuticals other respiratory system products other sex hormones and modulators of the genital system other systemic drugs for obstructive airway diseases other systemic hemostatics other therapeutic products other therapeutic radiopharmaceuticals other throat preparations other topical products for joint and muscular pain other urologicals other vasodilators used in cardiac diseases otologicals ovulation stimulants, synthetic oxazol, thiazine, and triazine derivatives oxazolidine derivatives oxicams oxytocin and analogues pain palliation (bone seeking agents) papaverine and derivatives paramagnetic contrast media parasympathomimetics penicillamine and similar agents penicillins with extended spectrum perchlorates peripheral opioid receptor antagonists peripheral vasodilators peripherally acting antiobesity products peroxides phenol and derivatives phenothiazine derivatives phenothiazines with aliphatic side-chain phenothiazines with piperazine structure phenothiazines with piperidine structure phenylalkylamine derivatives phenylpiperidine derivatives phosphatidylinositol-3-kinase (pi3k) inhibitors phosphodiesterase inhibitors phosphonic acid derivatives piperazine and derivatives piperazine derivatives piperidinedione derivatives pituitary and hypothalamic hormones and analogues plant alkaloids and other natural products platelet aggregation inhibitors excl. heparin podophyllotoxin derivatives poly (adp-ribose) polymerase (parp) inhibitors polymyxins posterior pituitary lobe hormones potassium pregnadien derivatives pregnen (4) derivatives preparations containing sulfur preparations for treatment of wounds and ulcers preparations increasing uric acid excretion preparations inhibiting uric acid production preparations with no effect on uric acid metabolism progesterone receptor modulators progestogens progestogens and estrogens in combination progestogens and estrogens, fixed combinations progestogens and estrogens, sequential preparations prolactine inhibitors propionic acid derivatives propulsives prostaglandin analogues prostaglandins protease inhibitors proteasome inhibitors protectives against uv-radiation protectives against uv-radiation for systemic use protectives against uv-radiation for topical use protein kinase inhibitors proton pump inhibitors psoralens for systemic use psoralens for topical use psychoanaleptics psycholeptics psycholeptics and psychoanaleptics in combination psychostimulants, agents used for adhd and nootropics purine analogues purine derivatives pyrazolone derivatives pyrazolones pyrethrines, incl. synthetic compounds pyrimidine analogues pyrimidine derivatives quaternary ammonium compounds quinine and derivatives quinoline derivatives quinoline derivatives and related substances quinolone antibacterials quinolone vasodilators rauwolfia alkaloids rauwolfia alkaloids and diuretics in combination renal system renin-inhibitors respiratory stimulants respiratory system retinoids for cancer treatment retinoids for topical use in acne retinoids for treatment of acne retinoids for treatment of psoriasis salicylic acid and derivatives salicylic acid derivatives salt solutions sclerosing agents for local injection second-generation cephalosporins secondary and tertiary amines selective beta-2-adrenoreceptor agonists selective calcium channel blockers with direct cardiac effects selective calcium channel blockers with mainly vascular effects selective estrogen receptor modulators selective immunosuppressants selective serotonin (5ht1) agonists selective serotonin reuptake inhibitors selenium sensitizers used in photodynamic/radiation therapy sensory organs serotonin (5ht3) antagonists serotonin receptor antagonists sex hormones and modulators of the genital system short-acting sulfonamides silver compounds skeleton sodium sodium-glucose co-transporter 2 (sglt2) inhibitors solutions affecting the electrolyte balance solutions producing osmotic diuresis somatostatin and analogues specific antirheumatic agents steroid antibacterials stomatological preparations streptomycins strophanthus glycosides substituted alkylamines substituted ethylene diamines succinimide derivatives sulfonamides sulfonamides (heterocyclic) sulfonamides and potassium in combination sulfonamides and trimethoprim sulfonamides, plain sulfonium derivatives sulfonylureas sulfur containing products sulfur-containing imidazole derivatives surgical aids sympathomimetics sympathomimetics excl. antiglaucoma preparations sympathomimetics in glaucoma therapy sympathomimetics used as decongestants sympathomimetics, combinations excl. corticosteroids sympathomimetics, labour repressants sympathomimetics, plain synthetic anticholinergic agents in combination with analgesics synthetic anticholinergic agents in combination with psycholeptics synthetic anticholinergics, esters with tertiary amino group synthetic anticholinergics, quaternary ammonium compounds synthetic estrogens, plain systemic hormonal preparations, excl. sex hormones and insulins taxanes technetium (99mtc) compounds technetium (99mtc), particles and colloids tertiary amines testosterone-5-alpha reductase inhibitors tests for bile duct patency tests for diabetes tests for fat absorption tests for fertility disturbances tests for gastric secretion tests for liver functional capacity tests for pituitary function tests for renal function and ureteral injuries tests for thyreoidea function tetracycline and derivatives tetracyclines tetrahydropyrimidine derivatives therapeutic radiopharmaceuticals thiazide derivatives thiazides and potassium in combination thiazides, combinations with other drugs thiazides, combinations with psycholeptics and/or analgesics thiazides, plain thiazolidinediones thiocarbamide derivatives thiouracils thioxanthene derivatives third-generation cephalosporins throat preparations thyroid thyroid hormones thyroid preparations thyroid therapy topical products for joint and muscular pain topoisomerase 1 (top1) inhibitors triazole and tetrazole derivatives triazole derivatives trimethoprim and derivatives tumour detection tyrosine hydroxylase inhibitors ultrasound contrast media urologicals uterotonics various various alimentary tract and metabolism products various pain palliation radiopharmaceuticals various therapeutic radiopharmaceuticals various thyroid diagnostic radiopharmaceuticals vascular endothelial growth factor receptor (vegfr) tyrosine kinase inhibitors vasodilators used in cardiac diseases vasopressin and analogues vasopressin antagonists vasoprotectives vinca alkaloids and analogues viscoelastic substances vitamin a and d, incl. combinations of the two vitamin a, plain vitamin b1, plain vitamin b1, plain and in combination with vitamin b6 and b12 vitamin b12 (cyanocobalamin and analogues) vitamin b12 and folic acid vitamin d and analogues vitamin k vitamin k and other hemostatics vitamin k antagonists vitamins watersoluble, hepatotropic x-ray contrast media watersoluble, nephrotropic, high osmolar x-ray contrast media watersoluble, nephrotropic, low osmolar x-ray contrast media x-ray contrast media, iodinated x-ray contrast media, non-iodinated xanthine derivatives xanthines xanthines and adrenergics yttrium (90y) compounds zinc